Biovendor Irisin Elisa Kit

Product Description

Summary

Fibronectin type III domain containing (FNDC) family consists of the multiple protein species but has a typified fibronectin type III domain (1-2). Among them FNDC5 also called irisin, hereinafter named irisin, has been identified a myokine which is capable of inducing browning of white adipose tissue leading to brown adipocytes and beige fat cells by stimulating UCP1 expression, via the PGC-1 transcriptional co-activator (3). Irisin is a single-pass type I membrane protein whose secretion could be by a putative signal peptide. Since irisin has been discovered as a soluble protein from the culture supernatant of the myocytes from the muscle-specific PGC-1 transgenic mice the predicted extracellular domain should be cleaved followed by being liberated from the cell surface membrane. Indeed, this was the case by having shown that the presence of the irisin exists in the culture supernatants and human/mouse sera as a 22 kDa protein (3). Irisin is able to induce UCP1 as well as a number of genes manifested in brown adipose tissues. In particular, the level of irisin was increased by muscular exercise in mouse and human, suggesting that irisin plays an important role in obesity and glucose homeostasis.