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C. Trachomatis is an intracellular parasite pathogen that is similar in cell wall structure to gram-negativebacteria. It is the most common sexually transmitted disease (STD) in the US with more than 4 million casesreported annually. The main sites of infection include the GU tract and rectum but conjunctivitis,perihepatitis and reactive arthritis may result. The infection is often asymptomatic, making it difficult todiagnose; as many as 2/3 of infected women are asymptomatic. Women develop mucopurulent cervicitis,and irregular menstrual bleeding or abdominal pain may occur in about 40% of these women. PID is foundin about 5% of women. The infection is usually symptomatic in men with dysuria and white/clear dischargeoccurring. Epididymitis is common. The infection incubates in 7 to 21 days and is commonly found with asecond STD pathogen. IgG and IgA antibodies to C. trachomatis can be detected with 2-4 weeks afterexposure. IgG remains positive, but the antibody level can drop overtime. ELISA can detect C. trachomatisIgM antibody for many months after infection.